Effects of compensatory growth on the levels of IGF-1, IGFBP-1 and expressions of IGF-1 mRNA, IGF-1R mRNA in <I>Carassius auratus gibelio</I>
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چکیده
منابع مشابه
Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats
Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues. This study aimed to evaluate the Igf-1r, Insr, and Igf-1 gene expression in colon and liver of streptozotocin-induced diabetic rats in response to insulin glarg...
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The zinc element (Zn) is one of the micronutrients and an essential element of the body which has some deleterious and irreparable effects on growth in case of lack it. Thus, we aimed to assess IGF-1 in goldfish with Zn deficiency and to investigate the effect of Zn supplementation on these parameters. Goldfish (Carassius auratus) juvenile (3.5 g) were fed purified diets based on casein as ...
متن کاملEffect of IGF-1 on Expression of GH Receptor, IGF-1, IGF-1 Receptor, KAP3.2 and KAP6-1 mRNA in the Skin of Sheep
Thirty-six healthy and similar Chinese Merino sheep were selected and divided into six groups at random. The treatment group was injected intradermally with 0.5 mL IGF-1 (10ng/mL). Treatment skin tissue of sheep were sampled respectively for 0,3,6,9,12 and 50 days and the skin expression of growth hormone receptor (GHR), insulin-like growth factor1 (IGF-1), insulin-like growth factor receptor (...
متن کاملThe mRNA expression of IGF-1 and IGF-1R in human breast cancer: association with clinico-pathological parameters
The principal pathways for transduction of the IGF signal are mitogen-activated protein kinase and phosphatidylinositol 3'-kinase [6,7]. After ligand-dependent receptor autophosphorylation, the IGF-IR phosphorylates a series of adaptor proteins, including insulin receptor substrate1, to activate intracellular signalling cascades [7]. The protein kinase pathway is responsible for the mitogenic s...
متن کاملEffects of Adenotonsillectomy on Serum Levels of IGF-1 and IGFBP-3 and Growth Indices in Children with Adenotonsillar Hypertrophy or Recurrent Tonsillitis
Introduction: Adenotonsillar hypertrophy (ATH) may present with growth retardation. Insulin-like growth factor 1 (IGF-1) mediates the anabolic effects of growth hormone (GH) on tissues. Most of the circulating IGF-1 molecules are bound to insulin-like growth factor-binding protein 3 (IGFBP-3). IGF-1 and IGFBP-3 serum levels reflect the levels of daily mean serum GH and are used as indices for e...
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ژورنال
عنوان ژورنال: Zoological Research
سال: 2013
ISSN: 0254-5853
DOI: 10.3724/sp.j.1141.2012.03298